|
KMID : 0043320110340101599
|
|
Archives of Pharmacal Research
2011 Volume.34 No. 10 p.1599 ~ p.1604
|
|
|
Isolation of phytosterols and antihyperlipidemic activity of Lagenaria siceraria
|
|
Kalsait Ravi P.
Khedekar Pramod B.
Saoji Ashok N.
Bhusari Kishor P.
|
|
|
Abstract
|
|
|
|
Lagenaria siceraria (Molina) Standl in the Cucurbitaceae family is a large, pubescent, climbing, or trailing herb cultivated throughout India and the tropical regions of the world. Phytochemical investigation of the methanol extract obtained from the fruits of the plant L. siceraria showed a positive Liebermann-Burchard test for sterols. The white sterol crystals or phytosterols from the methanol extract were isolated for the first time and identified as a mixture of four sterols, including fucosterol (1), racemosol (2), stigmasterol (3), and stigmasta-7,22-dien-3β,4β-diol (4). These compounds were identified by spectroscopic evidence including FTIR, 1H-NMR, MS, and GC. The white sterol crystals, which are the mixture of four sterols, were evaluated for antihyperlipidemic activity in Wistar rats. The blood samples were collected from the retro-orbital plexus and serum was separated and analyzed for lipid profiles. These sterol crystals (30 mg/kg) showed significant reductions in lipid profiles which included cholesterol, triglycerides, LDL and VLDL. In addition, a significant increase in HDL cholesterol observed, which is a good cholesterol that protects hearts from coronary artery diseases. These sterol crystals or phytosterols can be used as an antihyperlipidemic agent to treat the hyperlipidemic.
|
|
|
KEYWORD
|
|
|
Lagenaria siceraria, Phytosterols, Racemosol, Antihyperlipidemic
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|
|